Publications

2014

Yao L.C., C. Testini, D. Tvorogov, A. Anisimov, S.O. Vargas, P. Baluk,B. Pytowski, L. Claesson-Welsh, K. Alitalo, D.M. McDonald. Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circ Res. 114(5):806-22, 2014.

Yao L.C., D.M. McDonald. Plasticity of airway lymphatics in development and disease. Adv Anat Embryol Cell Biol. 214:41-54., 2014.

2013

Xi Y,Y. Wei, B. Sennino, A. Ulsamer, I. Kwan, A.N. Brumwell, K. Tan,M.K. Aghi, D.M. McDonald, D.M. Jablons, H.A. Chapman. Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia. Oncogene. 32(42):5048-57, 2013.

Khurana A., F. Chapelin, G. Beck, O.D. Lenkov, J. Donig, H. Nejadnik, S. Messing, N. Derugin, R.C. Chan, A. Gaur, B. Sennino, D.M. McDonald, P.J. Kempen, G.A. Tikhomirov, J. Rao, H.E. Daldrup-Link. Iron administration before stem cell harvest enables MR imaging tracking after transplantation. Radiology. 269(1):186-97, 2013.

Xu X., J. Greenland, P. Baluk, A. Adams, O. Bose, D.M. McDonald, G.H. Caughey. Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis. Am J Respir Cell Mol Biol. 49(3):437-44, 2013.

Miller C.N., D.J. Hartigan-O'Connor, M.S. Lee, G. Laidlaw, I.P. Cornelissen, M. Matloubian, S.R. Coughlin, D.M. McDonald, J.M. McCune. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 25(8):471-83.

Sennino, B., T. Ishiguro-Oonuma, B.J. Schriver, J.G. Christensen, D.M. McDonald Inhibition of c-Met reduces lymphatic metastasis in RIP-Tag2 transgenic mice. Cancer Res. 73(12):3692-703, 2013.

Baluk P., A. Hogmalm, M. Bry, K. Alitalo, K. Bry, D.M. McDonald Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways. Am J Pathol. 182(4):1434-47, 2013.

Morrisey E.E., W.V. Cardoso, R.H. Lane, M. Rabinovitch, S.H. Abman, X. Ai, K.H. Albertine, R.D. Bland, H.A. Chapman, W. Checkley, J.A. Epstein, C.R. Kintner, M. Kumar, P. Minoo, T.J. Mariani, D.M. McDonald, Y.S. Mukouyama, L.S. Prince, J. Reese, J. Rossant, W. Shi, X. Sun, Z. Werb, J.A. Whitsett, D. Gail, C.J. Blaisdell, Q.S. Lin. Molecular determinants of lung development. Ann Am Thorac Soc. 10(2):S12-6, 2013.

2012

Sennino, B., and D.M. McDonald. Controlling escape from angiogenesis inhibitors. Nat Rev Cancer. 12: 699-709, 2012.

Yao, L.C., P. Baluk, R.S. Srinivasan, G. Oliver, and D.M. McDonald. Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation. Am J Pathol. 180: 2561-2575, 2012.

Sennino, B., T. Ishiguro-Oonuma, Y. Wei, R.M. Naylor, C.W. Williamson, V. Bhagwandin, S.P. Tabruyn, W.K. You, H.A. Chapman, J.G. Christensen, D.T. Aftab, and D.M. McDonald. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov. 2: 270-287, 2012.

Henning, T.D., R. Gawande, A. Khurana, S. Tavri, L. Mandrussow, D. Golovko, A. Horvai, B. Sennino, D. McDonald, R. Meier, M. Wendland, N. Derugin, T.M. Link, and H.E. Daldrup-Link. Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells in cartilage defects: in vitro and in vivo investigations. Mol Imaging. 11: 197-209, 2012.

Cyran, C.C., B. Sennino, Y. Fu, V. Rogut, D.M. Shames, B. Chaopathomkul, M.F. Wendland, D.M. McDonald, R.C. Brasch, and H.J. Raatschen. Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF). Eur J Radiol. 81: 891-896, 2012.

Banfi, A., G. von Degenfeld, R. Gianni-Barrera, S. Reginato, M.J. Merchant, D.M. McDonald, and H.M. Blau. Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB. FASEB J. 26: 2486-2497, 2012.

2011

You, W.K., B. Sennino, C.W. Williamson, B. Falcon, H. Hashizume, L.C. Yao, D.T. Aftab, and D.M. McDonald. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res. 71: 4758-4768, 2011.

Witte, M.H., M.T. Dellinger, D.M. McDonald, S.D. Nathanson, F.M. Boccardo, C.C. Campisi, J.P. Sleeman, and J.E. Gershenwald. Lymphangiogenesis and hemangiogenesis: potential targets for therapy. J Surg Oncol. 103: 489-500, 2011.

McDonald, D.M., L.C. Yao, and P. Baluk. Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation. Proc Am Thorac Soc. 8: 504-507, 2011.

Lopez, J.I., I. Kang, W.K. You, D.M. McDonald, and V.M. Weaver. In situ force mapping of mammary gland transformation. Integr Biol (Camb). 3: 910-921, 2011.

Fuxe, J., S. Tabruyn, K. Colton, H. Zaid, A. Adams, P. Baluk, E. Lashnits, T. Morisada, T. Le, S. O'Brien, D.M. Epstein, G.Y. Koh, and D.M. McDonald. Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am J Pathol. 178: 2897-2909, 2011.

Falcon, B.L., K. Pietras, J. Chou, D. Chen, B. Sennino, D. Hanahan, and D.M. McDonald. Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B. Am J Pathol. 178: 2920-2930, 2011.

Falcon, B.L., S. Barr, P.C. Gokhale, J. Chou, J. Fogarty, P. Depeille, M. Miglarese, D.M. Epstein, and D.M. McDonald. Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res. 71: 1573-1583, 2011.

Aftab, D.T., and D.M. McDonald. MET and VEGF: synergistic targets in castration-resistant prostate cancer. Clin Transl Oncol. 13: 703-709, 2011.

2010

You, W.K., I. Kasman, D.D. Hu-Lowe, and D.M. McDonald. Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels. Am J Pathol. 176: 1927-1940, 2010.

Yao, L.C., P. Baluk, J. Feng, and D.M. McDonald. Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways. Am J Pathol. 176: 1525-1541, 2010.

Tabruyn, S.P., K. Colton, T. Morisada, J. Fuxe, S.J. Wiegand, G. Thurston, A.J. Coyle, J. Connor, and D.M. McDonald. Angiopoietin-2-driven vascular remodeling in airway inflammation. Am J Pathol. 177: 3233-3243, 2010.

Pham, T.H., P. Baluk, Y. Xu, I. Grigorova, A.J. Bankovich, R. Pappu, S.R. Coughlin, D.M. McDonald, S.R. Schwab, and J.G. Cyster. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 207: 17-27, 2010.

Ni, A., E. Lashnits, L.C. Yao, P. Baluk, and D.M. McDonald. Rapid remodeling of airway vascular architecture at birth. Dev Dyn. 239: 2354-2366, 2010.

Nedopil, A., C. Klenk, C. Kim, S. Liu, M. Wendland, D. Golovko, T. Schuster, B. Sennino, D.M. McDonald, and H.E. Daldrup-Link. MR signal characteristics of viable and apoptotic human mesenchymal stem cells in matrix-associated stem cell implants for treatment of osteoarthritis. Invest Radiol. 45: 634-640, 2010.

Mounzer, R.H., O.S. Svendsen, P. Baluk, C.M. Bergman, T.P. Padera, H. Wiig, R.K. Jain, D.M. McDonald, and N.H. Ruddle. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood. 116: 2173-2182, 2010.

McDonald, D.M. New antibody to stop tumor angiogenesis and lymphatic spread by blocking receptor partnering. Cancer Cell. 18: 541-543, 2010.

Hashizume, H., B.L. Falcon, T. Kuroda, P. Baluk, A. Coxon, D. Yu, J.V. Bready, J.D. Oliner, and D.M. McDonald. Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res. 70: 2213-2223, 2010.

Fuxe, J., E. Lashnits, S. O'Brien, P. Baluk, S.P. Tabruyn, F. Kuhnert, C. Kuo, G. Thurston, and D.M. McDonald. Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation. Am J Pathol. 176: 2009-2018, 2010.

Erzurum, S., S.I. Rounds, T. Stevens, M. Aldred, J. Aliotta, S.L. Archer, K. Asosingh, R. Balaban, N. Bauer, J. Bhattacharya, H. Bogaard, G. Choudhary, G.W. Dorn, 2nd, R. Dweik, K. Fagan, M. Fallon, T. Finkel, M. Geraci, M.T. Gladwin, P.M. Hassoun, M. Humbert, N. Kaminski, S.M. Kawut, J. Loscalzo, D. McDonald, I.F. McMurtry, J. Newman, M. Nicolls, M. Rabinovitch, J. Shizuru, M. Oka, P. Polgar, D. Rodman, P. Schumacker, K. Stenmark, R. Tuder, N. Voelkel, E. Sullivan, R. Weinshilboum, M.C. Yoder, Y. Zhao, D. Gail, and T.M. Moore. Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med. 182: 1554-1562, 2010.

Coxon, A., J. Bready, H. Min, S. Kaufman, J. Leal, D. Yu, T.A. Lee, J.R. Sun, J. Estrada, B. Bolon, J. McCabe, L. Wang, K. Rex, S. Caenepeel, P. Hughes, D. Cordover, H. Kim, S.J. Han, M.L. Michaels, E. Hsu, G. Shimamoto, R. Cattley, E. Hurh, L. Nguyen, S.X. Wang, A. Ndifor, I.J. Hayward, B.L. Falcon, D.M. McDonald, L. Li, T. Boone, R. Kendall, R. Radinsky, and J.D. Oliner. Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody. Mol Cancer Ther. 9: 2641-2651, 2010.

2009

Sennino, B., H.J. Raatschen, M.F. Wendland, Y. Fu, W.K. You, D.M. Shames, D.M. McDonald, and R.C. Brasch. Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic mice. Magn Reson Med. 62: 616-625, 2009.

Sennino, B., F. Kuhnert, S.P. Tabruyn, M.R. Mancuso, D.D. Hu-Lowe, C.J. Kuo, and D.M. McDonald. Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors. Cancer Res. 69: 4527-4536, 2009.

Okazaki, T., A. Ni, P. Baluk, O.A. Ayeni, J. Kearley, A.J. Coyle, A. Humbles, and D.M. McDonald. Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice. Am J Pathol. 174: 2388-2399, 2009.

Okazaki, T., A. Ni, O.A. Ayeni, P. Baluk, L.C. Yao, D. Vossmeyer, G. Zischinsky, G. Zahn, J. Knolle, C. Christner, and D.M. McDonald. alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation. Am J Pathol. 174: 2378-2387, 2009.

Henning, T.D., M.F. Wendland, D. Golovko, E.J. Sutton, B. Sennino, F. Malek, J.S. Bauer, D.M. McDonald, and H. Daldrup-Link. Relaxation effects of ferucarbotran-labeled mesenchymal stem cells at 1.5T and 3T: discrimination of viable from lysed cells. Magn Reson Med. 62: 325-332, 2009.

Falcon, B.L., H. Hashizume, P. Koumoutsakos, J. Chou, J.V. Bready, A. Coxon, J.D. Oliner, and D.M. McDonald. Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am J Pathol. 175: 2159-2170, 2009.

Dejana, E., F. Orsenigo, C. Molendini, P. Baluk, and D.M. McDonald. Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees. Cell Tissue Res. 335: 17-25, 2009.

Cyran, C.C., B. Sennino, B. Chaopathomkul, Y. Fu, V.S. Rogut, D.M. Shames, M.F. Wendland, D.M. McDonald, and R.C. Brasch. Magnetic resonance imaging for monitoring the effects of thalidomide on experimental human breast cancers. Eur Radiol. 19: 121-131, 2009.

Baluk, P., L.C. Yao, J. Feng, T. Romano, S.S. Jung, J.L. Schreiter, L. Yan, D.J. Shealy, and D.M. McDonald. TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest. 119: 2954-2964, 2009.

2008

You, W.K., and D.M. McDonald. The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis. BMB Rep. 41: 833-839, 2008.

Raatschen, H.J., G.H. Simon, Y. Fu, B. Sennino, D.M. Shames, M.F. Wendland, D.M. McDonald, and R.C. Brasch. Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in rats. Radiology. 247: 391-399, 2008.

McDonald, D.M. Angiogenesis and vascular remodeling in inflammation and cancer: Biology and architecture of the vasculature. In Angiogenesis: An Integrative Approach from Science to Medicine. W.D. Figg, and J. Folkman, editors. New York: Springer. Chapter 2, pp. 17-33, 2008.

Lewis, C.C., J.Y. Yang, X. Huang, S.K. Banerjee, M.R. Blackburn, P. Baluk, D.M. McDonald, T.S. Blackwell, V. Nagabhushanam, W. Peters, D. Voehringer, and D.J. Erle. Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med. 177: 376-387, 2008.

Kuhnert, F., B.Y. Tam, B. Sennino, J.T. Gray, J. Yuan, A. Jocson, N.R. Nayak, R.C. Mulligan, D.M. McDonald, and C.J. Kuo. Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis. Proc Natl Acad Sci U S A. 105: 10185-10190, 2008.

Korpisalo, P., H. Karvinen, T.T. Rissanen, J. Kilpijoki, V. Marjomaki, P. Baluk, D.M. McDonald, Y. Cao, U. Eriksson, K. Alitalo, and S. Yla-Herttuala. Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels. Circ Res. 103: 1092-1099, 2008.

Johnson, N.C., M.E. Dillard, P. Baluk, D.M. McDonald, N.L. Harvey, S.L. Frase, and G. Oliver. Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev. 22: 3282-3291, 2008.

Cyran, C.C., B. Sennino, B. Chaopathomkul, Y. Fu, V. Rogut, D.M. Shames, M.F. Wendland, D.M. McDonald, and R.C. Brasch. Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature. Invest Radiol. 43: 298-305, 2008.

Baluk, P., and D.M. McDonald. Markers for microscopic imaging of lymphangiogenesis and angiogenesis. Ann N Y Acad Sci. 1131: 1-12, 2008.

2007

Sennino, B., B.L. Falcon, D. McCauley, T. Le, T. McCauley, J.C. Kurz, A. Haskell, D.M. Epstein, and D.M. McDonald. Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res. 67: 7358-7367, 2007.

Ocak, I., P. Baluk, T. Barrett, D.M. McDonald, and P. Choyke. The biologic basis of in vivo angiogenesis imaging. Front Biosci. 12: 3601-3616, 2007.

McDonald, D.M. Imaging of angiogenesis in inflammation and cancer: lessons for novel treatment of allergic rhinitis. Clin Exp Allergy Rev. 7: 11Ð18, 2007.

Kim, K.E., C.H. Cho, H.Z. Kim, P. Baluk, D.M. McDonald, and G.Y. Koh. In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin. Arterioscler Thromb Vasc Biol. 27: 564-570, 2007.

Kamba, T., and D.M. McDonald. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer. 96: 1788-1795, 2007.

Henning, T.D., O. Saborowski, D. Golovko, S. Boddington, J.S. Bauer, Y. Fu, R. Meier, H. Pietsch, B. Sennino, D.M. McDonald, and H.E. Daldrup-Link. Cell labeling with the positive MR contrast agent Gadofluorine M. Eur Radiol. 17: 1226-1234, 2007.

Baluk, P., J. Fuxe, H. Hashizume, T. Romano, E. Lashnits, S. Butz, D. Vestweber, M. Corada, C. Molendini, E. Dejana, and D.M. McDonald. Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med. 204: 2349-2362, 2007.

Baluk, P., B.L. Falc—n, H. Hashizume, B. Sennino, and D.M. McDonald. Cellular actions of angiogenesis inhibitors on blood vessels. In Tumor Angiogenesis- Mechanisms and Cancer Therapy. D. MarmŽ, and N. Fusenig, editors. Berlin, Germany: Springer-Verlag GmbH. Chapter 32, pp. 557-576, 2007.

2006

Yao, V.J., M.G. Ozawa, A.S. Varner, I.M. Kasman, Y.H. Chanthery, R. Pasqualini, W. Arap, and D.M. McDonald. Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels. Cancer Res. 66: 2639-2649, 2006.

Xu, X., D. Zhang, N. Lyubynska, P.J. Wolters, N.P. Killeen, P. Baluk, D.M. McDonald, S. Hawgood, and G.H. Caughey. Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med. 173: 219-225, 2006.

Ramakrishnan, V., V. Bhaskar, D.A. Law, M.H. Wong, R.B. DuBridge, D. Breinberg, C. O'Hara, D.B. Powers, G. Liu, J. Grove, P. Hevezi, K.M. Cass, S. Watson, F. Evangelista, R.A. Powers, B. Finck, M. Wills, I. Caras, Y. Fang, D. McDonald, D. Johnson, R. Murray, and U. Jeffry. Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent. J Exp Ther Oncol. 5: 273-286, 2006.

Nakahara, T., S.M. Norberg, D.R. Shalinsky, D.D. Hu-Lowe, and D.M. McDonald. Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors. Cancer Res. 66: 1434-1445, 2006.

Mancuso, M.R., R. Davis, S.M. Norberg, S. O'Brien, B. Sennino, T. Nakahara, V.J. Yao, T. Inai, P. Brooks, B. Freimark, D.R. Shalinsky, D.D. Hu-Lowe, and D.M. McDonald. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest. 116: 2610-2621, 2006.

Kamba, T., B.Y. Tam, H. Hashizume, A. Haskell, B. Sennino, M.R. Mancuso, S.M. Norberg, S.M. O'Brien, R.B. Davis, L.C. Gowen, K.D. Anderson, G. Thurston, S. Joho, M.L. Springer, C.J. Kuo, and D.M. McDonald. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 290: H560-576, 2006.

Daly, C., E. Pasnikowski, E. Burova, V. Wong, T.H. Aldrich, J. Griffiths, E. Ioffe, T.J. Daly, J.P. Fandl, N. Papadopoulos, D.M. McDonald, G. Thurston, G.D. Yancopoulos, and J.S. Rudge. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci U S A. 103: 15491-15496, 2006.

Bhandari, V., R. Choo-Wing, S.P. Chapoval, C.G. Lee, C. Tang, Y.K. Kim, B. Ma, P. Baluk, M.I. Lin, D.M. McDonald, R.J. Homer, W.C. Sessa, and J.A. Elias. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A. 103: 11021-11026, 2006.

Baffert, F., T. Le, G. Thurston, and D.M. McDonald. Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules. Am J Physiol Heart Circ Physiol. 290: H107-118, 2006.

Baffert, F., T. Le, B. Sennino, G. Thurston, C.J. Kuo, D. Hu-Lowe, and D.M. McDonald. Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Am J Physiol Heart Circ Physiol. 290: H547-559, 2006.

2005

Yao, V.J., M.G. Ozawa, M. Trepel, W. Arap, D.M. McDonald, and R. Pasqualini. Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection. Am J Pathol. 166: 625-636, 2005.

Thurston, G., Q. Wang, F. Baffert, J. Rudge, N. Papadopoulos, D. Jean-Guillaume, S. Wiegand, G.D. Yancopoulos, and D.M. McDonald. Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period. Development. 132: 3317-3326, 2005.

Parsons-Wingerter, P., I.M. Kasman, S. Norberg, A. Magnussen, S. Zanivan, A. Rissone, P. Baluk, C.J. Favre, U. Jeffry, R. Murray, and D.M. McDonald. Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors. Am J Pathol. 167: 193-211, 2005.

Ozawa, M.G., V.J. Yao, Y.H. Chanthery, P. Troncoso, A. Uemura, A.S. Varner, I.M. Kasman, R. Pasqualini, W. Arap, and D.M. McDonald. Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma. Cancer. 104: 2104-2115, 2005.

OÕByrne, P.M., M.D. Inman, and D.M. McDonald. Experimental models of airway hyperresponsiveness. In Mucosal Immunology. J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock, J.R. McGhee, and L. Meyer, editors. Burlington, MA: Elsevier Academic Press. Chapter 81, pp. 1403-1414, 2005.

McDonald, D.M., and P. Baluk. Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lecture. Chest. 128: 602S-608S, 2005.

Magnussen, A., I.M. Kasman, S. Norberg, P. Baluk, R. Murray, and D.M. McDonald. Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels. Cancer Res. 65: 2712-2721, 2005.

di Tomaso, E., D. Capen, A. Haskell, J. Hart, J.J. Logie, R.K. Jain, D.M. McDonald, R. Jones, and L.L. Munn. Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers. Cancer Res. 65: 5740-5749, 2005.

Cho, C.H., K.E. Kim, J. Byun, H.S. Jang, D.K. Kim, P. Baluk, F. Baffert, G.M. Lee, N. Mochizuki, J. Kim, B.H. Jeon, D.M. McDonald, and G.Y. Koh. Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow. Circ Res. 97: 86-94, 2005.

Baluk, P., T. Tammela, E. Ator, N. Lyubynska, M.G. Achen, D.J. Hicklin, M. Jeltsch, T.V. Petrova, B. Pytowski, S.A. Stacker, S. Yla-Herttuala, D.G. Jackson, K. Alitalo, and D.M. McDonald. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest. 115: 247-257, 2005.

Baluk, P., H. Hashizume, and D.M. McDonald. Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev. 15: 102-111, 2005.

Aurora, A.B., P. Baluk, D. Zhang, S.S. Sidhu, G.M. Dolganov, C. Basbaum, D.M. McDonald, and N. Killeen. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol. 175: 6319-6326, 2005.

2004

Ozawa, C.R., A. Banfi, N.L. Glazer, G. Thurston, M.L. Springer, P.E. Kraft, D.M. McDonald, and H.M. Blau. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest. 113: 516-527, 2004.

McDonald, D.M., B.A. Teicher, W. Stetler-Stevenson, S.S. Ng, W.D. Figg, J. Folkman, D. Hanahan, R. Auerbach, M. O'Reilly, R. Herbst, D. Cheresh, M. Gordon, A. Eggermont, and S.K. Libutti. Report from the society for biological therapy and vascular biology faculty of the NCI workshop on angiogenesis monitoring. J Immunother. 27: 161-175, 2004.

Lee, C.G., H. Link, P. Baluk, R.J. Homer, S. Chapoval, V. Bhandari, M.J. Kang, L. Cohn, Y.K. Kim, D.M. McDonald, and J.A. Elias. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 10: 1095-1103, 2004.

Inai, T., M.R. Mancuso, D.M. McDonald, J. Kobayashi, K. Nakamura, and Y. Shibata. Shear stress-induced upregulation of connexin 43 expression in endothelial cells on upstream surfaces of rat cardiac valves. Histochem Cell Biol. 122: 477-483, 2004.

Inai, T., M. Mancuso, H. Hashizume, F. Baffert, A. Haskell, P. Baluk, D.D. Hu-Lowe, D.R. Shalinsky, G. Thurston, G.D. Yancopoulos, and D.M. McDonald. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol. 165: 35-52, 2004.

Baluk, P., W.W. Raymond, E. Ator, L.M. Coussens, D.M. McDonald, and G.H. Caughey. Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling. Am J Physiol Lung Cell Mol Physiol. 287: L307-317, 2004.

Baluk, P., C.G. Lee, H. Link, E. Ator, A. Haskell, J.A. Elias, and D.M. McDonald. Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways. Am J Pathol. 165: 1071-1085, 2004.

Baffert, F., G. Thurston, M. Rochon-Duck, T. Le, R. Brekken, and D.M. McDonald. Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels. Circ Res. 94: 984-992, 2004.

2003

McDonald, D.M., and P.L. Choyke. Imaging of angiogenesis: from microscope to clinic. Nat Med. 9: 713-725, 2003.

Favre, C.J., M. Mancuso, K. Maas, J.W. McLean, P. Baluk, and D.M. McDonald. Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung. Am J Physiol Heart Circ Physiol. 285: H1917-1938, 2003.

Denis-Mize, K.S., M. Dupuis, M. Singh, C. Woo, M. Ugozzoli, D.T. O'Hagan, J.J. Donnelly, 3rd, G. Ott, and D.M. McDonald. Mechanisms of increased immunogenicity for DNA-based vaccines adsorbed onto cationic microparticles. Cell Immunol. 225: 12-20, 2003.

Baluk, P., S. Morikawa, A. Haskell, M. Mancuso, and D.M. McDonald. Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am J Pathol. 163: 1801-1815, 2003.

2002

Umemoto, E.Y., J.J. Brokaw, M. Dupuis, and D.M. McDonald. Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infection. Cell Immunol. 220: 107-115, 2002.

Pasqualini, R., W. Arap, and D.M. McDonald. Probing the structural and molecular diversity of tumor vasculature. Trends Mol Med. 8: 563-571, 2002.

Morikawa, S., P. Baluk, T. Kaidoh, A. Haskell, R.K. Jain, and D.M. McDonald. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol. 160: 985-1000, 2002.

McDonald, D.M., and P. Baluk. Significance of blood vessel leakiness in cancer. Cancer Res. 62: 5381-5385, 2002.

2001

Veikkola, T., L. Jussila, T. Makinen, T. Karpanen, M. Jeltsch, T.V. Petrova, H. Kubo, G. Thurston, D.M. McDonald, M.G. Achen, S.A. Stacker, and K. Alitalo. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J. 20: 1223-1231, 2001.

Pasqualini, R., D.M. McDonald, and W. Arap. Vascular targeting and antigen presentation. Nat Immunol. 2: 567-568, 2001.

McDonald, D.M. Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am J Respir Crit Care Med. 164: S39-45, 2001.

Kwan, M.L., A.D. Gomez, P. Baluk, H. Hashizume, and D.M. McDonald. Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. Am J Physiol Lung Cell Mol Physiol. 280: L286-297, 2001.

Gale, N.W., P. Baluk, L. Pan, M. Kwan, J. Holash, T.M. DeChiara, D.M. McDonald, and G.D. Yancopoulos. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol. 230: 151-160, 2001.

Ezaki, T., P. Baluk, G. Thurston, A. La Barbara, C. Woo, and D.M. McDonald. Time course of endothelial cell proliferation and microvascular remodeling in chronic inflammation. Am J Pathol. 158: 2043-2055, 2001.

Elson, D.A., G. Thurston, L.E. Huang, D.G. Ginzinger, D.M. McDonald, R.S. Johnson, and J.M. Arbeit. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes Dev. 15: 2520-2532, 2001.

Dupuis, M., K. Denis-Mize, A. LaBarbara, W. Peters, I.F. Charo, D.M. McDonald, and G. Ott. Immunization with the adjuvant MF59 induces macrophage trafficking and apoptosis. Eur J Immunol. 31: 2910-2918, 2001.

2000

Thurston, G., J.S. Rudge, E. Ioffe, H. Zhou, L. Ross, S.D. Croll, N. Glazer, J. Holash, D.M. McDonald, and G.D. Yancopoulos. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med. 6: 460-463, 2000.

Thurston, G., K. Maas, A. Labarbara, J.W. McLean, and D.M. McDonald. Microvascular remodelling in chronic airway inflammation in mice. Clin Exp Pharmacol Physiol. 27: 836-841, 2000.

Thurston, G., P. Baluk, and D.M. McDonald. Determinants of endothelial cell phenotype in venules. Microcirculation. 7: 67-80, 2000.

McDonald, D.M., L. Munn, and R.K. Jain. Vasculogenic mimicry: how convincing, how novel, and how significant? Am J Pathol. 156: 383-388, 2000.

McDonald, D.M., and A.J. Foss. Endothelial cells of tumor vessels: abnormal but not absent. Cancer Metastasis Rev. 9: 109-120, 2000.

Hashizume, H., P. Baluk, S. Morikawa, J.W. McLean, G. Thurston, S. Roberge, R.K. Jain, and D.M. McDonald. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol. 156: 1363-1380, 2000.

Dupuis, M., K. Denis-Mize, C. Woo, C. Goldbeck, M.J. Selby, M. Chen, G.R. Otten, J.B. Ulmer, J.J. Donnelly, G. Ott, and D.M. McDonald. Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J Immunol. 165: 2850-2858, 2000.

Denis-Mize, K.S., M. Dupuis, M.L. MacKichan, M. Singh, B. Doe, D. O'Hagan, J.B. Ulmer, J.J. Donnelly, D.M. McDonald, and G. Ott. Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells. Gene Ther. 7: 2105-2112, 2000.

Chang, Y.S., E. di Tomaso, D.M. McDonald, R. Jones, R.K. Jain, and L.L. Munn. Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci U S A. 97: 14608-14613, 2000.

1999

Thurston, G., C. Suri, K. Smith, J. McClain, T.N. Sato, G.D. Yancopoulos, and D.M. McDonald. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science. 286: 2511-2514, 1999.

Murphy, T.J., G. Thurston, T. Ezaki, and D.M. McDonald. Endothelial cell heterogeneity in venules of mouse airways induced by polarized inflammatory stimulus. Am J Pathol. 155: 93-103, 1999.

McDonald, D.M., G. Thurston, and P. Baluk. Endothelial gaps as sites for plasma leakage in inflammation. Microcirculation. 6: 7-22, 1999.

Corada, M., M. Mariotti, G. Thurston, K. Smith, R. Kunkel, M. Brockhaus, M.G. Lampugnani, I. Martin-Padura, A. Stoppacciaro, L. Ruco, D.M. McDonald, P.A. Ward, and E. Dejana. Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci U S A. 96: 9815-9820, 1999.

1998

Thurston, G., T.J. Murphy, P. Baluk, J.R. Lindsey, and D.M. McDonald. Angiogenesis in mice with chronic airway inflammation: strain-dependent differences. Am J Pathol. 153: 1099-1112, 1998.

Thurston, G., J.W. McLean, M. Rizen, P. Baluk, A. Haskell, T.J. Murphy, D. Hanahan, and D.M. McDonald. Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice. J Clin Invest. 101: 1401-1413, 1998.

Suri, C., J. McClain, G. Thurston, D.M. McDonald, H. Zhou, E.H. Oldmixon, T.N. Sato, and G.D. Yancopoulos. Increased vascularization in mice overexpressing angiopoietin-1. Science. 282: 468-471, 1998.